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教員情報 |
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タナカ ナツミ 田中 なつみ リハビリテーション学部 理学療法学科 助教 |
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■ 標題 Myonuclear apoptosis via cleaved caspase-3 upregulation is related to macrophage accumulation underlying immobilization-induced muscle fibrosis |
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■ 概要 Although macrophage accumulation plays a key role in the development of immobilization-induced muscle fibrosis, the underlying mechanisms remain unclear. Therefore, we focused on the alterations of myonuclear apoptosis via cleaved caspase-3, and investigated whether these changes may be related to macrophage accumulation. In the result, myonuclear apoptosis via the upregulation of cleaved caspase-3 might induce macrophage accumulation. These alterations are related to immobilizationinduced muscle fibrosis. ◎Natsumi Tanaka, Yuichiro Honda, Yasuhiro Kajiwara, Hideki Kataoka, Tomoki Origuchi, Junya Sakamoto, Minoru Okita 共著 Muscle Nerve 65(3),pp.341-349 2022/03 |
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