タカヤマ　マキ
  高山　真希   リハビリテーション学部 理学療法学科   助教
■ 標題
  Association between Preoperative Long-Chain Polyunsaturated Fatty Acids and Oxidative Stress Immediately after Total Knee Arthroplasty: A Pilot Study
■ 概要
  This study aimed to examine whether preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio are associated with oxidative stress immediately after TKA.Fourteen eligible patients with knee osteoarthritis scheduled for unilateral
TKA participated in this study. The levels of serum EPA, DHA, and AA were measured immediately before surgery. Derivatives of reactive oxygen metabolites (d-ROMs) were used as biomarkers for oxidative stress. The preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio were found to be significantly negatively correlated with the serum d-ROM levels at 96 h after surgery, and the rate of increase in serum d-ROM levels between baseline and 96 h postoperatively. This study suggested the preoperative serum EPA + DHA levels and the (EPA + DHA)/AA ratio can be negatively associated with oxidative stress immediately after TKA.
  ◎Yusuke Kubo, Masae Ikeya, Shuhei Sugiyama, Rie Takachu, Maki Tanaka, Takeshi Sugiura,Kaori Kobori and Makoto Kobori
  共著   Nutrients   13(6),pp.2093   2021/06